Blinding in trials of interventional procedures is possible and worthwhile [version 2; referees: 3 approved]

In this paper, we use evidence from Can Punch / Bottle Openers our earlier review of surgical randomised controlled trials with a placebo arm to show that blinding in trials of interventional procedures is feasible.We give examples of ingenious strategies that have been used to simulate the active procedure and to make the placebo control indistinguishable from the active treatment.We discuss ORG SWEETENED CONDENSED COCONUT MILK why it is important to blind of patients, assessors, and caregivers and what types of bias that may occur in interventional trials.Finally, we describe the benefits of blinding, from the obvious ones such as avoiding bias, as well as less evident benefits such as avoiding patient drop out in the control arm.